Adrenoleukodystrophy is an X-linked recessive disease. A disease is X-linked when the mutation occurs on the X--or female--chromosome. Males have one X and one Y chromosome, while females have two X's. All the X chromosomes have to be mutated to have this disease because it is recessive. This makes the disease much more prevalent in males then in females--who can have a "back up" healthy X.
http://www.medic8.com/genetics/xlinked-adrenoleukodystrophy.htm
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