There is a wide range of severity of Lorenzo's Oil that have been broken down into the categories below:
Childhood cerebral ALD. Childhood cerebral ALD the second most common form of Adrenoleukodystrophy. Symptoms begins between the ages of 2 and 10. Until then, development is normal. The most common symptoms are difficulty in school, behavioral disturbance, impaired vision, or impaired hearing. After first symptoms neurological symptoms appear and the health of the patients get worse. Further symptoms may include dementia, poor coordination, seizures, hyperactivity, difficulty with speech, and headaches. On average, a person lives about 2 years before being bedridden or dead.
Adolescent cerebral ALD. A small portion of Adrenoleukodystrophy patients have symptoms occur from 11-21 years old. Symptoms include stiffness/clumsiness in the legs, weight loss, attacks of nausea, and generalized weakness, difficulty with walking, urinary disturbance, cognitive defects, emotional disturbances, and depression. This form of the disease progresses slower and withing 15 years, a person would need aid walking.
Adult cerebral ALD. Adult cerebral ALD is relatively rare. First symptoms occur between the 20s and 50s The symptoms are similar to those of dementia. The progression of the disorder is rapid. Someone will usually be bedridden or dead within 3 to 5 years.
Symptomatic heterozygotes. Women have two copies of the X chromosome, which is where the mutated gene for Adrenoleukodystrophy is. Some women who carry one healthy copy and one mutated copy of the gene. These people are heterozygous and sometimes do show some symptoms of Adrenoleukodystrophy. The symptoms can range from very mild to very severe. They are similar those of other Adrenoleukodystrophy patients, with the exception that heterozygote women rarely have impaired adrenal function.
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